SELECTED PUBLICATIONS:
Lin H, Safdar MH, Dagher S, Akhand SS, Dickerhoff J, Ayers M, Solorio L, Yang D, Wendt MK. FGFR1 expression is regulated by G-quadruplex in metastatic breast cancer. Communications Biology. Aug 9;7(1):963 (2024).

-Coleman MF, Kuloylouoglu Cotul E, Pfeil AJ, Devericks EN, Safdar MH, Chen H, Ho AN, Attaar N, Malian HM, Kiesel VA, Ramos A, Smith M, Panchal H, Mailloux A, Teegarden D, Hursting SD, Wendt MK. Hypoxia-mediated suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression. Breast Cancer Research. June 7;26(1):96. (2024)

-Herndon ME, Ayers M, Gibson-Corley K, Wendt MK, Wallrath LL, Henry MD, and Stipp CS. The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial-mesenchymal phenotype. Disease Models and Mechanisms. Sep 1;17(9)(2024).
-Kulkoyluoglu Cotul E, Paez JS, Hassan Safdar M, Kulkarni A, Ayers MG, Lin H, Xianyu Z, Teegarden D, Hursting S, Wendt MK. FGFR1 signaling facilitates obesity-driven pulmonary outgrowth in metastatic breast cancer. (2023) MCR-23-0955.

-Chen H, Cresswell GM, Libring S, Ayers MG, Miao J, Zhang ZY, Solorio L, Ratliff TL,  Wendt MK. Tumor-cell autonomous SHP2 contributes to immune suppression in metastatic breast cancer, Can Res Comm. Sept 1st, 2022.
 
- Aparna Shinde, Eylem Kulkoyluoglu Cotul, Hao Chen, Andrew Smith, Sarah Libring, Luis Solorio & Michael K. Wendt. Transglutaminase-2 mediates acquisition of neratinib resistance in metastatic breast cancer. Mol Bio Med. June 22nd 2022.

-Saeed S Akhand, Hao Chen, Stephen Connor Purdy, Zian Liu, Joshua C Anderson, Christopher D Willey, Michael K Wendt. Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy. NPJ Breast Cancer Jan 21st 2021.

-Abdullah A, Akhand SA, Paez JS, Brown W, Pan L, Libring S, Badamy M, Dykuizen E, Solorio L, Tao WA, Wendt MK. Epigenetic targeting of neuropilin-1 prevents bypass signaling in drug resistant breast cancer. Oncogene. Oct. 30th 2020.

- Saeed S Akhand, Zian Liu, Stephen Connor Purdy, Ammara Abdullah, Hang Lin, Gregory M. Cresswell, Timothy L. Ratliff and Michael K. Wendt. Pharmacological inhibition of FGFR modulates the metastatic immune microenvironment and promotes response to immune checkpoint blockade. Cancer Immunology Research, 2020 Oct 22nd. doi: 10.1158/2326-6066.CIR-20-0235

- Hao Chen, Sarah Libring, Kasi Viswanatharaju Ruddraraju, Jinmin Miao, Luis Solorio, Zhong-Yin Zhang & Michael K. Wendt. SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer. Oncogene, 2020 Oct 8th.

-Shinde A, Paez JS, Libring S, Hopkins K, Solorio L, Wendt MK. Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche. Oncogenesis, 2020; 9: 16.

-Shinde A, Hardy SD, Kim D, Salehin Akhand S, Jolly MK, Wang W, Anderson JC, Khodadadi RB, Brown WS, George JT , Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, Geahlen RL, Wendt MK. Spleen tyrosine kinase-mediated autophagy is required for epithelial-mesenchymal plasticity and breast cancer metastasis. Cancer Research, 2019 Apr 15;79(8):1831-1843.
Featured as cover
Comment on article: Lulling the Cancer Cell into an Eternal Sleep. Cancer Research. 2019 Apr 15;79(8):1756-1757

-Ali R, Brown W, Purdy SC, Davisson VJ, Wendt MK. Biased signaling downstream of epidermal growth factor receptor regulates proliferative versus apoptotic response to ligand. Cell Death and Disease; 9: 976 (2018).

-Shinde A, Wilmanski T, Chen H, Teegarden D, Wendt MK. Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer. Breast Cancer Research. 2018. 20:76.

-Aparna Shinde, Sarah Libring, Aktan Alpsoy, Ammara Abdullah, James A Schaber, Luis Solorio and Michael K. Wendt. Autocrine Fibronectin Inhibits Breast Cancer Metastasis. Molecular Cancer Research 2018 ePub June 22nd

-Hardy SD, Shinde A, Wang WH, Wendt MK*, Geahlen RL*. Regulation of EMT and metastasis by TGF-beta, P-bodies, and autophagy. Oncotarget 2017. ePub Oct 17th

- Bartolowits MD*, Brown W*, Ali R, Pedley Am, Chen Q, Harvey KE, Wendt MK, Davisson VJ. Selective inhibition of STAT3 Phosphorylation using a nuclear-Targeted kinase inhibitor. ACS Chem Bio 2017. ePub Sep 15th.

- Brown WS,  Akhand SS, Wendt MK. FGFR signaling maintains a drug persistent cell population following epithelial-mesenchymal transition. Oncotarget
2016. ePub November 4

-Brown WS, Tan L, Smith AS, Gray NS, Wendt MK. Covalent targeting of FGFR inhibits metastatic breast cancer. Mol Can Therapeutics.
2016. ePub July 1
SEMINAR LINKS:
University of Colorado, Cancer Biology Training Program
Pharmacological targeting of Metastatic Breast cancer. 

REVIEWS:
-Violet A. Kiesel, Madeline P. Sheeley, Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt & Dorothy Teegarden. Pyruvate carboxylase and cancer progression. Cancer and Metabolism. April 30th 2021. 

- Ali R, Wendt MK. The paradoxical function of EGFR during breast cancer progression. Signal Transduction and Targeted Therapy. 2017. Epub Jan 20.

-Brown WS, Wendt MK. Integrin-mediated resistance to epidermal growth factor receptor-targeted therapy: an inflammatory situation. Breast Cancer Research.
2014. Sept. 16(5):448.

-Wendt MK, Tian M, Schiemann WP. Deconstructing the mechanisms and consequences of TGF-b-induced EMT during cancer progression. CTR.
Epub 2011 June 21.

-Wendt MK, Balanis N*, Carlin CR, Schiemann WP. Stat3 and Epithelial-Mesenchymal Transitions in carcinomas. JAKSTAT, 2014 Jan;3(1)e28975.